Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity

J Med Chem. 2000 Sep 7;43(18):3372-6. doi: 10.1021/jm000143w.
No abstract available

MeSH terms

  • Acoustic Stimulation
  • Aniline Compounds / chemical synthesis*
  • Aniline Compounds / chemistry
  • Aniline Compounds / pharmacology
  • Animals
  • Anticonvulsants / chemical synthesis
  • Anticonvulsants / chemistry
  • Anticonvulsants / pharmacology
  • Antioxidants / chemical synthesis*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Calcium Channel Blockers / chemical synthesis*
  • Calcium Channel Blockers / chemistry
  • Calcium Channel Blockers / pharmacology
  • Cerebral Cortex / metabolism
  • In Vitro Techniques
  • Lipid Peroxidation / drug effects
  • Mice
  • Mice, Inbred DBA
  • Models, Molecular
  • Molecular Conformation
  • Neuroprotective Agents / chemical synthesis
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / pharmacology
  • Piperazines / chemical synthesis*
  • Piperazines / chemistry
  • Piperazines / pharmacology
  • Rats
  • Seizures / drug therapy
  • Sodium Channel Blockers*

Substances

  • Aniline Compounds
  • Anticonvulsants
  • Antioxidants
  • Calcium Channel Blockers
  • Neuroprotective Agents
  • Piperazines
  • SUN N8075
  • Sodium Channel Blockers